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In Vivo Model Construction of Plaque Biofilm

In Vivo Model Construction of Plaque Biofilm

Dental plaque is the main factor causing caries and periodontal disease, and controlling the growth of plaque is of great significance for preventing and treating caries and periodontal disease. Most of the plaque structures are studied by In Vivo single bacterial culture or in vivo fixed time sampling electron microscope scanning. However, dental plaque is not a single bacteria, but is formed continuously by a three-dimensional spatial structure wrapped by a matrix. Therefore, these experimental methods are difficult to observe the continuous structural features of intact natural plaque biofilms in humans. Therefore, it is necessary to establish a dental plaque biofilm model in vivo to observe the structural characteristics of biofilms at different times of formation. We provide In vivo model construction of plaque biofilm service, which facilitates the study of a series of biological activities of plaque in the host, such as metabolic level and drug resistance.

Our Services

CD BioSciences provides one-stop in vivo model construction of plaque biofilm service. We offer a variety of methods and equipment to choose from to meet your research needs. CD BioSciences will build a dental plaque biofilm model for you, and observe the characteristics of natural plaque biofilm formation at different times.

In Vivo Model Construction of Plaque Biofilm Approaches We Offer

  • Construction Methods

CD BioSciences established a dental plaque biofilm model with reference to the Zaura-Arite and Wood plaque collection methods [1-2], and collected continuous and complete plaque biofilms in vivo. Confocal laser scanning microscopy (CLSM) was used to observe the structural characteristics of biofilms at different times within 48 hours of formation. In addition, we can also evaluate the penetration and bactericidal effects of antibiotics on naturally formed intact biofilms.

  • Image Analysis

The scanned images of each sample were packaged for screening analysis in Leica Confocal Software Lite.

  • Statistical Processing

All data are expressed as x±s, and SPSS software is used for statistical analysis. Randomized block one-way analysis of variance (one-way ANOVA) was performed between each observation index of plaques formed in different periods, and SNK (Student-Neuman-Keuls) multiple comparisons were performed for pairwise comparison of means. Analysis and SNK method were used for pairwise comparison of means. P < 0.05 was considered a statistically significant difference.

Our Advantages

  • Advanced biofilm technology platform
  • Professional biofilm technology experts
  • Adaptable to high throughput workflows
  • Simple and fast workflow

Provided by Clients

Please inform us of your specific in vivo model construction of plaque biofilm service details, and we can provide customized solutions for different projects.

Service Process

Service Process

Our Features

  • CD BioSciences has a group of technical experts specializing in biofilm construction. Our extensive research and technical experience can help our customers solve their biofilm construction technical problems.
  • CD BioSciences has a proven, advanced biofilm technology platform that is constantly being improved to ensure that we can provide accurate, sensitive, and rapid analytical results for our customers.


  • Results of plaque biofilm model construction
  • Service quality inspection report
  • Related experimental results raw data
  • Data analysis
  • Image and result analysis

Why Choose Us?

CD BioSciences is a company that provides professional and comprehensive biofilm services. We have years of experience to meet your specific project needs in using biofilm research to add value to your research projects. CD BioSciences can provide you with personalized solutions to help you thrive every step of the way around your interest in your workflow. If you would like to know more details about biofilm service, please feel free to contact us.


  1. Zaura-Arite E, van Marle J, ten Cate JM. Confocal microscopy study of undisturbed and chlorhexidine-treated dental biofilm. J Dent Res, 2001, 80(5): 1436-1440.
  2. Wood SR, Kirkham J, Marsh PD, et al. Architecture of intact natural human plaque biofilms studied by confocal laser scanning microscopy. J Dent Res, 2000, 79(5):21-27.
For research use only, not intended for any clinical use.
Related Services:

CD BioSciences is a specialized company providing biofilm services with expertise in the intersection of chemistry and biophysics. Our platform offers advanced technologies to meet all your biofilm needs.

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