Application of Biofilms in Pharmacy

• Application of Biofilms in New Dosage Forms

Liposomes and vesicles have a bilayer structure similar to biological membranes as a drug delivery system with strong membrane affinity to increase drug bioavailability. The immobilization of liposomes or vesicles on a matrix is commonly used for chromatography, i.e. immobilized liposome chromatography. The interaction between monomeric drugs, precursor drugs and simulated biofilms was investigated using DSC and Langmuir-Blodgett methods^[1-2].

• Application of Biofilms in Pharmacokinetic

The absorption, distribution, metabolism and excretion of drugs in absorption, distribution, metabolism and excretion of drugs in the body are all related to drug-membrane interactions and cell membrane permeability. Whether a candidate drug can be used as a drug depends largely on its passive transport absorption rate and the permeability of biofilms and physiological membrane barriers. Immobilized phospholipid membrane chromatography is made by chemically bonding monolayer or multilayer phospholipid membranes to a certain matrix to make chromatographic packing. The oral utilization of clinical oral drugs is a key factor affecting drug efficacy using simulated biofilms can predict the oral absorption of drugs in vitro. Jingoish et al. used IAM analysis of drugs with different structures to predict the absorption of orally administered drugs based on their chromatographic retention values and found that drugs with relative molecular mass less than 200 and oral absorption not greater than 90% were more suitable for biofilm chromatography analysis and the results correlated better with in vivo measurements^[3].

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CD BioSciences has in-depth cooperation with many biology companies and research institutes, and has extensive experience in providing them with high-quality services. CD BioSciences provides professional biofilm service to meet the needs of regular customers to determine hits on time and on budget. CD BioSciences relies on the world-class technical expertise, we provide customers with the best quality one-stop biofilm service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

References

1. Sarpietro M G, Michelin D, Rocco F et al. Conjugation of squalene to acyclovir improves the affinity for biomembrane models．International Journal of Pharmaceutics. 2009. 382：73.
2. Castelli F, Sarpietro M G, Micieli D, et al．Enhancement of gemcitabine affinity for biomembranes by conjugation with squalene：Differential scanning calorimetry and Langmuir-Blodgett studies using biomembrane models. Journal Colloid and Interface Science. 2007, 316：4.3
3. Kotecha J, Shah S, Rathod I, et al．Relationship between immobilized artificial membrane chromatographic retention and human oral absorption of structurally diverse drugs．International Journal Pharmaceutics.2007,333:127.

• Application of Biofilms in Pharmacology
• Application of Biofilms in Chromatography