Introductions

Chromatography is a method to separate and analyze substances according to the difference in partition coefficients between the stationary phase and the mobile phase. It can be divided into liquid chromatography, gas chromatography and supercritical fluid chromatography according to the molecular aggregation state of the mobile phase. According to the separation principle, it can be divided into many categories, such as adsorption, distribution, spatial repulsion, ion exchange, affinity and chiral chromatography. According to the operation principle, it can be divided into column chromatography and plate chromatography, etc. Chromatography has become one of the most widely used and accepted analytical methods in pharmacopoeias. Biofilms are the most basic organizational units in living systems. They separate cells and organelles from the surrounding medium, forming many tiny compartments with specific functions to maintain the concentration and potential differences between the two sides of the membrane. Biofilms are a very active research area in molecular biology, cell biology, chemical biology and soft condensed matter physics.

Application of Biofilms in Chromatography

• Recent studies have usually used chemical simulation to build biofilm simulation systems such as chromatographic analysis systems. Commonly used biofilm simulation systems are: immobilized liposomes or vesicles immobilized phospholipid membranes activated cell membranes, etc.
• Most drug molecules or ions can only be effective if they enter the cell and interact with specific cells, and most of the targets of action are located in the cell membrane. The interaction between drugs and membranes can be studied by using simulated or reconstructed biological membranes. The most studied ones are cell membrane chromatography and immobilized liposome chromatography, which are mostly used for pharmaceutical studies.
• Chromatographic coupling techniques for drug analysis, such as the combination of biochromatography with HPLC, MS, IR spectroscopy and NMR, allow simultaneous screening and determination of active ingredients. This method can be used to predict the absorption of a compound in vivo and thus to study the substance basis of the drug effect.

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• Application of Biofilms in Pharmacology
• Application of Biofilms in Pharmacy