Bacterial biofilm refers to a large number of bacterial aggregated membrane-like substances formed by bacteria adhering to the contact surface, secreting polysaccharide matrix, fibrin, lipid protein, and surrounding itself. Bacteria can form biofilms under different environmental conditions, such as pH, temperature, nutrients, etc. Therefore, the growth of biofilms is an extremely robust process. Therefore, while biofilm growth is a complex process influenced by multiple variables, insights into biofilm formation can be gained by studying simple schematic models. CD BioSciences use computer-aided methods to provide computational modeling service of early-stage biofilm formation to help customers complete biofilm related research.

Figure 1. Five stages of biofilm development. (Filippini P, et al. 2001)

Specific Modeling Approaches We Offer

• We provide a hybrid molecular dynamics and Monte Carlo model for simulating the early formation of biofilms to unequivocally demonstrate that most of the expected relevant processes can be explained.
• Our simulations account for bacterial growth and reproduction, their interactions and motility, and the synthesis of extracellular polymers and exopolysaccharide trajectories.
• We can describe the production of EPS as the growth of the extracellular matrix, in a coarse-grained manner, by numerical settings. Our model is sufficient to identify key physical processes that play a role in the early formation of biofilms.

Provided by Clients

Please inform us of your specific computational modeling service of early-stage biofilm formation system details, and we can provide customized solutions for different projects.   

Service Process

Our Features

Deliverables

Why Choose Us?

CD BioSciences provides professional biofilm modeling services to meet the scientific research needs of customers. CD BioSciences relies on world-class technical expertise, we provide customers with the highest quality one-stop biofilm modeling services, including the development of experimental procedures according to different experimental needs. We are happy to discuss your project and the potential of applying biofilm construction with you. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

Reference

1. Filippini P, Rainaldi G, Ferrante A, et al. Evaluation of the effects of extremely low frequency (ELF) electromagnetic fields on the growth and cell cycle distribution of osteosarcoma cells. 2001.

• Biofilm Computational Construction Service
• Biofilm Molecular Dynamics Simulation Service
• Stability Test of Biofilm System
• RMSF Analysis of Biofilm System
• Gyration Radius Analysis of Biofilm System
• Binding Mode Analysis of Biofilm System
• Secondary Structure Analysis of Biofilm System
• Energy Analysis of Biofilm System
• Hydrophobic Interaction Analysis of Biofilm System
• Free Energy Landscape Analysis of Biofilm System
• Biofilm Conformational Principal Component Analysis
• Biofilm Ramachandran Plots Analysis
• Cluster Analysis of Biofilm System
• SAS Analysis Service of Biofilm System
• Energy Decomposition Analysis of Biofilm System
• Electrostatic Interaction Analysis of Biofilm System
• Biofilm Virtual Screening Service
• Biofilm CGMD Service
• Biofilm DPD Service
• Biofilm DEM Service
• Biofilm SPH Service
• Biofilm XFEM Service
• Other Biofilm MD Serivce
• Biofilm Homology Modeling Serivce
• Gram-negative Bacterial Outer Membrane Construction Service
• Biofilm Formation Simulation Service
• Construction Services for Discrete Difference Models
• Modeling Services for Geometric Heterogeneity in Biofilms
• Computational Simulation Service for Biofilm Development
• Computational Modeling Service for Synthetic Biofilms
• Biofilm MD Results Analysis Services
• Biofilm Multiscale Computational Modeling Service
• Biofilm Modeling Service