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Computational Modeling of Early-Stage Biofilm Formation

Bacterial biofilm refers to a large number of bacterial aggregated membrane-like substances formed by bacteria adhering to the contact surface, secreting polysaccharide matrix, fibrin, lipid protein, and surrounding itself. Bacteria can form biofilms under different environmental conditions, such as pH, temperature, nutrients, etc. Therefore, the growth of biofilms is an extremely robust process. Therefore, while biofilm growth is a complex process influenced by multiple variables, insights into biofilm formation can be gained by studying simple schematic models. CD BioSciences use computer-aided methods to provide computational modeling service of early-stage biofilm formation to help customers complete biofilm related research.

Five stages of biofilm development.Figure 1. Five stages of biofilm development. (Filippini P, et al. 2001)

Specific Modeling Approaches We Offer

  • We provide a hybrid molecular dynamics and Monte Carlo model for simulating the early formation of biofilms to unequivocally demonstrate that most of the expected relevant processes can be explained.
  • Our simulations account for bacterial growth and reproduction, their interactions and motility, and the synthesis of extracellular polymers and exopolysaccharide trajectories.
  • We can describe the production of EPS as the growth of the extracellular matrix, in a coarse-grained manner, by numerical settings. Our model is sufficient to identify key physical processes that play a role in the early formation of biofilms.

Provided by Clients

Please inform us of your specific computational modeling service of early-stage biofilm formation system details, and we can provide customized solutions for different projects.   

Service Process

Service Process

Our Features

  • CD BioSciences has bioscientists with extensive biofilm research experience and can provide customers with a range of biofilm simulation services.
  • CD BioSciences works closely with clients to meet their needs in the final step of delivering results. With all our in-house expertise and experience, we are confident to solve any challenges you may have during your biofilm service.
  • CD BioSciences researchers can quickly understand the project situation through a simple description, and quickly develop a feasible research plan according to customer needs.



  1. Related experimental results raw data
  2. Stability assessment report
  3. Image and result analysis
  4. Bacterial growth and reproduction process
  5. Interaction and movement details
  6. Extracellular polymer synthesis details
  7. Summary of relevant calculation parameters

Why Choose Us?

CD BioSciences provides professional biofilm modeling services to meet the scientific research needs of customers. CD BioSciences relies on world-class technical expertise, we provide customers with the highest quality one-stop biofilm modeling services, including the development of experimental procedures according to different experimental needs. We are happy to discuss your project and the potential of applying biofilm construction with you. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.


  1. Filippini P, Rainaldi G, Ferrante A, et al. Evaluation of the effects of extremely low frequency (ELF) electromagnetic fields on the growth and cell cycle distribution of osteosarcoma cells. 2001.
For research use only, not intended for any clinical use.
Related Services:

CD BioSciences is a specialized company providing biofilm services with expertise in the intersection of chemistry and biophysics. Our platform offers advanced technologies to meet all your biofilm needs.

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