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Free Energy Landscape Analysis of Biofilm System

The free energy landscape (FEL) calculation is obtained by sampling trajectories starting from different peptide conformations. It shows the valleys and hills of free energy experienced by the peptide throughout the simulation. In addition, in the docking calculation FEL becomes more meaningful when a representative structure needs to be chosen. FEL represents a mapping from all possible conformations that a molecule undergoes during a simulation to the corresponding energies. A typical energy is the Gibbs free energy. Therefore, FEL It is usually expressed using two variables, which reflect specific properties of the system and characterize conformational changes. CD BioSciences use computer-aided methods to provide free energy landscape analysis of biofilm system to help customers complete biofilm related research.

Our Services

CD BioSciences provides one-stop free energy landscape analysis service of biofilm system. We offer a variety of methods and software to choose from to meet your research needs.

Specific Free Energy Landscape Analysis Approaches We Offer

  • CD BioSciences use the GROMACS command sham to calculate the FEL. For a better experience, we provide some additional scripts and display them directly.
  • We will calculate two variables to represent the free energy. To represent the conformational change of the polypeptide, we calculate its radius of gyration, and the RMSD relative to the mean structure.
  • We do not use the native state because that would disrupt subsequent docking simulations. Also, we can compute these variables based on the merged trajectories. A prerequisite for computing the FEL is adequate sampling, or repeating long simulations with different initial velocities, or As we have done, start the simulation from a different conformation.

Provided by Clients

Please inform us of your specific free energy landscape analysis of biofilm system details, and we can provide customized solutions for different projects.

Service Process

Service Process

Our Features

  • CD BioSciences will complete your project on time and efficiently. We have professional after-sales service.
  • CD BioSciences collaborates with scientists from many pharmaceutical and biotechnology companies. We have a wealth of knowledge and experience to provide quality assurance services.


  1. Related experimental results raw data
  2. Analysis results of free energy landscape
  3. Experimental report
  4. Data analysis
  5. Image and result analysis
  6. Summary of relevant calculation parameters

Why Choose Us?

CD BioScience is a well-known nanocage service provider and supports most of the biofilm related services. CD BioScienceis is committed to improving various biofilm related services. We are able to design and complete a set of services as solutions for themed projects. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

For research use only, not intended for any clinical use.
Related Services:

CD BioSciences is a specialized company providing biofilm services with expertise in the intersection of chemistry and biophysics. Our platform offers advanced technologies to meet all your biofilm needs.

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