In the last few years, there has been a culmination of DEM-based numerical biofilm models addressing different problems of biofilms. Among the numerous biofilm models, most of the proposed DEM biofilm models can couple physical and biological processes, some of which cannot include biological metabolism, to quantify biofilm interactions with the external environment. One of the main motivations for biofilm research is the production of extracellular polymeric substances (EPS) by bacterial communities as an externally engineered matrix to adhere and protect cells from drugs and environmental changes. Several proposed DEM models can successfully simulate EPS and can be used as a potential tool to study EPS mechanisms using biofilms as ELM. CD BioSciences use computer-aided methods to provide DEM service to help customers complete biofilm related research.

Specific DEM Approaches We Offer

• The most widely used biofilm modeling approach for our construction of biofilms is the discrete element method (DEM), where biofilm modeling they are mostly referred to as individual-based modeling (IbM) or agent-based modeling (AbM).
• During DEM modeling, a single bacterial cell is usually identified as a single element, while replication and interactions are based on different biomathematical models. It is particularly suitable for biofilm modeling because it successfully couples and accurately describes hydrodynamics, thermodynamics, biological processes, etc., and can serve as a bridge between individual and population level behavior.
• Most of the proposed DEM biofilm models in DEM construction can couple physical and biological processes, some of which cannot include biological metabolism, to quantify biofilm interactions with the external environment.
• In addition, we provide professional results analysis, image processing, data aggregation and other services.

Provided by Clients

Please inform us of your specific biofilm DEM service details, and we can provide customized solutions for different projects.      

Service Process

Our Features

Why Choose Us?

CD BioSciences is a professional biofilm technology provider, supporting a variety of biofilm modeling services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. CD BioSciences has many years of experience in biofilm testing technology services and has been a trusted partner to our clients for a long time. If you are looking for these services, you can contact us at any time and we look forward to a pleasant relationship with you.

Reference

1. Hanfeng Zhai, et al. Multiscale Computational Modeling of Biofilm. 2022

• Biofilm Computational Construction Service
• Biofilm Molecular Dynamics Simulation Service
• Stability Test of Biofilm System
• RMSF Analysis of Biofilm System
• Gyration Radius Analysis of Biofilm System
• Binding Mode Analysis of Biofilm System
• Secondary Structure Analysis of Biofilm System
• Energy Analysis of Biofilm System
• Hydrophobic Interaction Analysis of Biofilm System
• Free Energy Landscape Analysis of Biofilm System
• Biofilm Conformational Principal Component Analysis
• Biofilm Ramachandran Plots Analysis
• Cluster Analysis of Biofilm System
• SAS Analysis Service of Biofilm System
• Energy Decomposition Analysis of Biofilm System
• Electrostatic Interaction Analysis of Biofilm System
• Biofilm Virtual Screening Service
• Computational Modeling of Early-Stage Biofilm Formation
• Biofilm CGMD Service
• Biofilm DPD Service
• Biofilm SPH Service
• Biofilm XFEM Service
• Other Biofilm MD Serivce
• Biofilm Homology Modeling Serivce
• Gram-negative Bacterial Outer Membrane Construction Service
• Biofilm Formation Simulation Service
• Construction Services for Discrete Difference Models
• Modeling Services for Geometric Heterogeneity in Biofilms
• Computational Simulation Service for Biofilm Development
• Computational Modeling Service for Synthetic Biofilms
• Biofilm MD Results Analysis Services
• Biofilm Multiscale Computational Modeling Service
• Biofilm Modeling Service