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Application of Biofilms in Cancer



Cancer is a multifactorial disease, the treatment of solid tumors and biofilm-derived infections faces a common problem: drugs often fail to reach and kill cancer cells and microbial pathogens due to the heterogeneity of the local microenvironment. There are significant challenges for current and future anti-cancer and anti-biofilm drugs to target and maintain activity in the microenvironment where cancer cells and microbial pathogens survive and cause disease onset. Bacterial infections in cancer formation will increase in the coming years. A collection of approaches such as ROS regulation in cells where microbial inflammation promotes tumors could be a strategy to target cancer and bacteria.

Application of Biofilms in Cancer

Application of Biofilm in Digestive Tract Cancer

  • Application of Biofilm in Digestive Tract Cancer

H. pylori forms biofilms not only on abiotic surfaces, but also on biotic surfaces. Human cell lines can mimic in vivo cell behavior and can be used for ex vivo biofilm assays. The ex vivo model also includes biofilm growth on natural tissues in a minimally variable environment, providing more tightly controlled experimental conditions than the in vivo model and thus allowing for more detailed studies.

Application of Biofilm in Colon Cancer

  • Application of Biofilm in Colon Cancer

The vast majority of biofilm-covered tissue is found in patients with right-sided colon cancer, close to the hepatic flexure, raising questions about the relationship between the microbiome and site-specific cancers. Biofilms from sporadic colorectal cancer (CRC) hosts are associated with a pro-carcinogenic altered metabolome and epithelial cell biology, and in the context of cancer, perhaps the most relevant association is increased epithelial cell proliferation.

Application of Biofilm in Colorectal Cancer

  • Application of Biofilm in Colorectal Cancer

Among the various environmental factors thought to contribute to colorectal cancer risk, new data suggest that dense bacterial communities of biofilms may play an important role, at least in some areas of the colon. Biofilms are groups of microorganisms that grow on surfaces and adhere to each other. Biofilms have been identified in the colon of some patients with colonic adenomas and colon cancer.

Our Related Services

  • Quantitative Analysis of Bacteria in Biofilms               
  • Biofilm Imaging Services              
  • Biofilm Genomics and Metagenomics Services            
  • Biofilm Transcriptomics Services          
  • Biofilm Proteomics Services          
  • Biofilm Metabolomics Services             
  • Biofilm TOC Analysis Services             
  • Interaction Analysis of Biofilm Community 

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