Microbial biofilms are complex, self-organizing bacterial communities that utilize physiological cooperation and spatial organization to increase their metabolic efficiency and resistance to local environmental changes. These properties make biofilms attractive targets for engineering, especially for the production of chemicals such as pharmaceutical ingredients or biofuels, with the potential to significantly increase yields and reduce maintenance costs. Biofilms are also a major cause of persistent infection, and a better understanding of their organization could lead to new strategies for destruction. Despite this potential, the design of synthetic biofilms remains a major challenge due to the complex interplay between transcriptional regulation, cell-to-cell signaling, and cellular biophysics. CD BioSciences use computer-aided methods to provide computational modeling services for synthetic biofilms to help customers complete biofilm related research.

Specific Computational Simulation Approaches We Offer

• Computational modeling services from CD BioSciences can help address this challenge by predicting the behavior of synthetic biofilms before they are built;
• We provide a computational method for simulating synthetic microbial biofilms that combines three-dimensional biophysical models of individual cells with models of genetic regulation and intercellular signaling.
• Our method is implemented in the form of specific software that scales to over 30,000 cells, typically colonies 100 μm in diameter, within 30 minutes of computation time using a parallel graphics processing unit architecture.
• In addition, we provide professional results analysis, image processing, data aggregation and other services.

Provided by Customers

Please inform us of your specific computational modeling service for synthetic biofilms details, and we can provide customized solutions for different projects.

Service Process

Our Features

Deliverables

1. Related experimental results raw data
2. Simulation results
3. Image and result analysis
4. Interaction and movement details
5. Summary of relevant calculation parameters

Why Choose Us?

CD BioSciences provides professional computational modeling service for synthetic biofilms. We will meet the specific needs of customers on time and on budget. CD BioSciences relies on world-class technical expertise, we provide customers with the highest quality one-stop service, including the development of solutions according to different scientific research needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.  

Reference

1. Hanfeng Zhai, et al. Multiscale Computational Modeling of Biofilm. 2022

• Biofilm Computational Construction Service
• Biofilm Molecular Dynamics Simulation Service
• Stability Test of Biofilm System
• RMSF Analysis of Biofilm System
• Gyration Radius Analysis of Biofilm System
• Binding Mode Analysis of Biofilm System
• Secondary Structure Analysis of Biofilm System
• Energy Analysis of Biofilm System
• Hydrophobic Interaction Analysis of Biofilm System
• Free Energy Landscape Analysis of Biofilm System
• Biofilm Conformational Principal Component Analysis
• Biofilm Ramachandran Plots Analysis
• Cluster Analysis of Biofilm System
• SAS Analysis Service of Biofilm System
• Energy Decomposition Analysis of Biofilm System
• Electrostatic Interaction Analysis of Biofilm System
• Biofilm Virtual Screening Service
• Computational Modeling of Early-Stage Biofilm Formation
• Biofilm CGMD Service
• Biofilm DPD Service
• Biofilm DEM Service
• Biofilm SPH Service
• Biofilm XFEM Service
• Other Biofilm MD Serivce
• Biofilm Homology Modeling Serivce
• Gram-negative Bacterial Outer Membrane Construction Service
• Biofilm Formation Simulation Service
• Construction Services for Discrete Difference Models
• Modeling Services for Geometric Heterogeneity in Biofilms
• Computational Simulation Service for Biofilm Development
• Biofilm MD Results Analysis Services
• Biofilm Multiscale Computational Modeling Service
• Biofilm Modeling Service