Modeling the structural development of biofilms is a formidable challenge due to the complex interplay between many processes. Biofilm development is determined by "positive" processes such as cell attachment, cell division, and polymer formation, leading to volume expansion of biofilms, while "negative" processes, such as cell detachment and cell death, lead to biofilm contraction. By changing the balance between these two types of processes, biofilms with different structural properties such as porosity, compactness or surface roughness can be formed. CD BioSciences use computer-aided methods to provide construction services for discrete difference models to help customers complete biofilm related research.

Specific Construction Approaches We Offer

• CD BioSciences has developed a fully quantitative 2D and 3D method for biofilm growth and structure formation.
• Our model incorporates flow over irregular biofilm surfaces, convective and diffusive mass transfer of substrates, bacterial growth, and bacterial diffusion.
• Upon customer request, our model will also include biofilm detachment mechanisms due to biofilm deformation stress. Models can accommodate arbitrarily shaped carrier surfaces, as well as multi-species and multi-matrix biofilms.

Our Service Process

• First, a hydrodynamic step is performed. The momentum transfer and continuity equations are solved to find the flow field variables
• The second step uses the flow rate U just calculated to solve for mass transfer of soluble components, conyectjye-djffusiye.
• The new biomass S content of each grid element. Cx, is calculated by using the Monod and Herbert-Pirt equations, including the previously calculated substrate concentration at steady state.
• As the biomass grows, it must be redistributed in space.
• The separation step can also be performed before redistribution, since the separation time constant is in the same range as the growth time.

Provided by Customers

Please inform us of your specific construction services for discrete difference models details, and we can provide customized solutions for different projects.

Service Process

Our Features

Deliverables

1. Related experimental results raw data
2. Simulation results
3. Image and result analysis
4. Interaction and movement details
5. Summary of relevant calculation parameters

Why Choose Us?

CD BioSciences is a professional biofilm technology provider, supporting a variety of biofilm discrete difference models construction services. We can perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. CD BioSciences has accumulated years of quintessence in the field of biofilm eradication, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. For more details on how we can support your project with innovation, please feel free to contact us.

Reference

1. Hanfeng Zhai, et al. Multiscale Computational Modeling of Biofilm. 2022

• Biofilm Computational Construction Service
• Biofilm Molecular Dynamics Simulation Service
• Stability Test of Biofilm System
• RMSF Analysis of Biofilm System
• Gyration Radius Analysis of Biofilm System
• Binding Mode Analysis of Biofilm System
• Secondary Structure Analysis of Biofilm System
• Energy Analysis of Biofilm System
• Hydrophobic Interaction Analysis of Biofilm System
• Free Energy Landscape Analysis of Biofilm System
• Biofilm Conformational Principal Component Analysis
• Biofilm Ramachandran Plots Analysis
• Cluster Analysis of Biofilm System
• SAS Analysis Service of Biofilm System
• Energy Decomposition Analysis of Biofilm System
• Electrostatic Interaction Analysis of Biofilm System
• Biofilm Virtual Screening Service
• Computational Modeling of Early-Stage Biofilm Formation
• Biofilm CGMD Service
• Biofilm DPD Service
• Biofilm DEM Service
• Biofilm SPH Service
• Biofilm XFEM Service
• Other Biofilm MD Serivce
• Biofilm Homology Modeling Serivce
• Gram-negative Bacterial Outer Membrane Construction Service
• Biofilm Formation Simulation Service
• Modeling Services for Geometric Heterogeneity in Biofilms
• Computational Simulation Service for Biofilm Development
• Computational Modeling Service for Synthetic Biofilms
• Biofilm MD Results Analysis Services
• Biofilm Multiscale Computational Modeling Service
• Biofilm Modeling Service