Bacterial Infections

Bacterial biofilms are complex surface attached communities of bacteria held together by self-produced polymer matrixs mainly composed of polysaccharides, secreted proteins, and extracellular DNAs. Explicit direct observations have identified bacteria that cause device-associated and other chronic infections growing in matrix-enclosed biofilms. Diagnostic and therapeutic strategies that have served us well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable results when applied to these biofilm diseases.

Application of Biofilms in Bacterial Infections

• Biofilms as Self-Assembling Multicellular Communities

When planktonic bacteria encounter a surface or interface, they adhere to the interface in a reversible manner while"exploring" the area to determine if it provides a nutritional or other advantage. Biofilm formation and biofilm separation are both controlled by the same types of chemical signals that regulate community sensing, and these regulatory molecules direct the formation of mucus-enclosed microcolonies and water channels. Biofilms form in many high shear environments, such as the vegetation that forms on natural heart valves, so these material properties are closely related and can be used to predict when and where fragments will separate and where they will end up in the flow system.

• Biofilms as Protected Sessile Communities

One of the most important protections provided by biofilm growth patterns is against desiccation and UV light. These sequestered communities are particularly popular and highly visible in intermittent wet splash zones of freshwater and marine ecosystems, where these communities allow prokaryotic cells to survive all day in dry and intense sunlight and to rejuvenate upon rehydration.

• Biofilm as a Distinct, Signal-Controlled Phenotype

The simple observation that microbial biofilms are composed of structured microcolonies and that water channels are created and maintained suggests that certain types of cell-cell signaling systems must function in these multicellular communities. Biofilms dominate most ecosystems, and these sequestered cells express genes that we have never seen before and reach levels of interaction and community behavior that we have never imagined.

Our Related Services

• Natural Compound Biofilm Eradication Technical Service
• Phage Biofilm Eradication Technical Services
• Biofilm Elimination Services on Medical Devices
• Biofilm Drug Resistance Gene Testing 
• Biofilm and Drug Interaction Testing    
• Biofilm Antibacterial Efficacy Testing  
• Biofilm Inhibition or Destruction Testing     

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• Application of Biofilms in Cancer
• Application of Biofilm in Dermatology
• Application of Biofilms in Chronic Infectious Diseases
• Application of Biofilms in Blood Purification
• Application of Biofilm in Medical Device Infection
• Application of Biofilms in Immunotherapy