Application of Biofilms in Pharmacology

• Application of Biofilms in Drug Binding to Serum Proteins

Immobilization of biological macromolecules on substrates such as silica gel or gels to produce molecular biochromatography mimics biofilms at the molecular level. The binding of drugs to human serum protein (HSA) affects their in vivo processes and, to some extent, their efficacy. Serum protein column chromatography can be used to study the binding of drugs and HSA. HSA binding and the effect of metal ions on drug-serum protein conjugation. The effect of metal ions on drug-serum protein interaction was investigated.

• Application of Biofilms in Predicting Pharmacological Activity of Drugs

Immobilization of active cell membranes in substrates to make cell membrane chromatography can predict the pharmacological activity of newly synthesized compounds pharmacological activity of newly synthesized compounds for large throughput screening of drug candidates in drug discovery. It can be used for large throughput screening of drug candidates in drug discovery. Many drugs have pharmacological activity but in vivo safety and efficacy are not suitable for clinical application so there is a need to modify the drug into different precursor drugs using biofilms to quickly screen for the ideal precursor drug.

• Application of Biofilms in the Study of Cytotoxic Compounds

Aromatic compounds are toxic and tend to accumulate in the body. Biofilm models can be used to study these cytotoxic substances in vitro. Scientist used liposome electrokinetic chromatography to predict the toxicity of some aromatic compounds and found a negative correlation between the retention values of the compounds and various known ecotoxicity coefficients and a positive correlation with the bioaccumulation coefficients.

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• Application of Biofilms in Pharmacy
• Application of Biofilms in Chromatography