Bacteria in biofilms are inherently more resistant to antimicrobial treatments when compared directly to planktonic cells of the same strain. The mechanisms of antibiotic resistance in planktonic bacteria are usually well known, and these same mechanisms (mutations, efflux pumps, and antibiotic-modifying enzymes) do not appear to be the primary cause of biofilm-mediated antibiotic resistance. Therefore, biofilm antibiotic resistance (BAT) is thought to involve alternative mechanisms of bacterial antimicrobial resistance.BAT has been defined as the ability of bacteria in the presence of biofilms to survive antimicrobial therapy by using their available genetic complement. Now, CD BioSciences provides you with a variety of biofilm BAT eradication services to meet your scientific research needs.

Biofilm BAT Eradication Service Approaches We Offer

CD BioSciences offer a professional biofilm BAT eradication service. the mechanisms that induce BAT appear to be more complex than the predisposing factors that cause the phenomenon, and only a few studies on the subject are less well understood. Antimicrobial treatments represent an important stress signal for biofilm-resident cells, and it is therefore reasonable to assume that antimicrobial treatments could select for biofilm-specific antimicrobial resistance genes that would contribute to BAT.

We perform biofilm elimination services by modulating the triggers of BAT, including:

• Restricted Penetration

EPS of biofilms has long been considered as a major contributor to BAT. However, the supporting evidence in this regard is conflicting. EPS of several biofilm-forming species have been shown to have an innate ability to prevent antibiotic penetration.

• Reduced Growth Rate

Although restriction of pentaphylaxis does not always explain BAT, reduced growth rates appear to play a more pronounced role in BAT.

• Persistent Cells

The prevalence of persistent cells in biological membranes is probably the most plausible innate mechanism for BAT described so far, and although persistent cells do not directly contain antimicrobial resistance genes, they certainly provide a perfect platform for the development of drug-resistant mutants. Therefore, we focused our efforts on studying the mechanisms of persistent cell formation.

Provided by Clients

Please inform us of your specific biofilm BAT eradication services details, and we can provide customized solutions for different projects.   

Service Process

Our Features

Why Choose Us?

CD BioSciences offers biofilm BAT eradication service to researchers who wish to benefit from this technology. With talented biofilm technologists and state-of-the-art facilities, we offer integrated, ready-to-use solutions. We are happy to discuss your project and the potential of applying biofilm service with you. Our excellent technology platform can realize a variety of biofilm technology services and solve all difficulties encountered in research for customers. If you would like to know more details about biofilm service, please feel free to contact us. We will ensure to provide you with efficient and high-quality experimental outsourcing services.

Reference

1. Anthony D.Verderosa, et al. Bacterial Biofilm Eradication Agents: A Current Review. Frontiers in Chemistry. 2019.

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